Photo by Pittendreigh
Although certainly observed by Messier, it was not added to the catalogue and given and M-number until 1947.
M106 is in the constellation of Canes Venatici, but the guide stars that I recommend using for this object are in Ursa Major, so find the Big Dipper. Notice the top outside rim of the cup and the and the inside bottom of the cup.
These are Alpha and Gamma. Draw a line from Alpha, through Gamma and continue for about 3/4ths that distance.
Slowly scan this area. On a good night, you might be able to see it in the view finder.
My eyes always catch a glimpse of a tight triangle of stars in the area. These point toward M106.
WHAT TO LOOK FOR:
M106 will appear as a long elliptical haze.