On a star chart M50 will look like it is in the middle of nowhere, with no bright stars close by.
Don't worry, M50 is easy. Just find Sirius and Procyon, which are two rather bright stars that will be easy to locate. Scan the area between these stars, moving from Sirius to Procyon. M50 is one-third of the way toward Procyon. A pair of binoculars will spot it. A very low power viewfinder will reveal a nebulous spot.
WHAT TO LOOK FOR:
Binoculars will show M50 as a cluster of a half dozen stars with a hazy background. A telescope with greater power will show more of the 80 or so stars in the cluster. Some observers will see a heart shape within the cluster.